An MYB‐family transcription factor with suber powers

Blimp-1 Expression as an Exhaustion Transcription Factor in Chronic Lymphocytic Leukemia

Background: PPreviously, it was shown that exhausted CD4+ and CD8+ T cells in chronic lymphocytic leukemia (CLL) co-express the two immune-inhibitory receptors, Tim-3 and PD-1. Present study investigated the expression of Blimp-1, a transcription factor involved in T cell exhaustion, in patients with CLL. Materials and Methods: Peripheral blood mononuclear cells were collected from 25 untreate...

metabolic syndrome and mitochondrial transcription factor a

TFE, an archaeal transcription factor in Methanobacterium thermoautotrophicum related to eucaryal transcription factor TFIIEalpha.

In the archaeon Methanobacterium thermoautotrophicum, MTH1669 encodes a protein with a sequence related to the N-terminal sequences of the alpha-subunits of eucaryal general transcription factor TFIIE. The recombinant MTH1669 gene product has been purified and shown to stimulate transcription in vitro from M. thermoautotrophicum promoters that were almost inactive or much less active in reactio...

Discovering Motifs With Transcription Factor Domain Knowledge

We introduce a new motif-discovery algorithm, DIMDom, which exploits two additional kinds of information not commonly exploited: (a) the characteristic pattern of binding site classes, where class is determined based on biological information about transcription factor domains and (b) posterior probabilities of these classes. We compared the performance of DIMDom with MEME on all the transcript...

Linking Transcription Factor Expression with DNA Binding